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The Illustrious Members of the Myong Lab


PRINCIPAL INVESTIGATOR, Sua Myong (smyong1@jhu.edu)

Sua obtained her B.S in Molecular Cellular Biology and Ph.D in Nutrition/Biochemistry from the University of California, Berkeley. She received biophysics training in her postdoctorate years. She loves being a scientist! Her research interest is driven by unsolved biomedical problems including cancer and neurodegeneration. If she did not become a scientist, she would have chosen a path in medicine, music or engineering. In her spare time, she enjoys singing, playing piano, painting and cooking.

 

POSTDOCTORATE, Ramreddy Tippana (rtippan1@jhu.edu)

Ramreddy Tippana obtained his Ph.D. in chemistry at Tata Institute of Fundamental Research (TIFR), Mumbai, India. Currently, he is investigating the role of G-quadruplexes (GQ) on gene expression and regulation in vitro and in vivo. His study also includes how the presence G-quadruplex resolving helicases (either by overexpressing or knocking down the helicases in human cells) effect the GQ dependent gene regulation in Hela, HEK or U2OS cells. In his work, he employs a wide variety of biophysics and molecular biology techniques like the single-molecule FRET, luciferase assay, polysome profiling and single molecule RNA FISH. Furthermore, he is also interested in measuring strength and dynamics of a wide variety of GQ conformations by using custom built nanopore setup. By obtaining the information on GQ stalling and resolving ability of various DNA unwinding helicases could help us to develop better helicases for nanopore sequencing.

Ram

 

POSTDOCTORATE, Jaya Sarkar (jsarkar1@jhu.edu)

Jaya graduated with a Ph.D. in Biochemistry from the University of Illinois at Urbana-Champaign (UIUC), where she investigated enzyme mechanisms and protein-RNA interactions in aminoacyl tRNA synthetase-based fidelity of protein synthesis. She then studied enzymatic mechanisms in DNA damage repair and telomere maintenance at the National Institutes of Health (NIH). In the Myong lab, Jaya works on molecular mechanisms of liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) found in ribonucleoprotein particles (RNP), and mutations in which cause neurodegenerative diseases including ALS. Specifically, Jaya focuses on the molecular basis of how RNA and RNA-IDP interactions modulate phase properties of FUS in vitro and in cellular aggregates, and early stage events that lead to pathological inclusions. For this, she uses a combination of single molecule biophysical and ensemble biochemical techniques.

 

POSTDOCTORATE, Hui-Ting Lee (hlee154@jhu.edu)

Ting obtained her Ph.D. in Pharmaceutical Science from University of Nebraska Medical Center. Her Ph.D. work focuses on the physical chemistry of non-canonical DNA secondary structures, such as pseudoknots, triplexes, G-quadruplexes, and i-motifs, which play various biological roles in protein binding and gene regulation. She studied ribozyme folding in crowding environment using small angle X-ray scattering (SAXS) and RNA footprinting for her first postdoctoral project in Dr. Sarah Woodson’s lab in Johns Hopkins. Currently, she is using single-molecule methods to study the stress-induced telomere conformation change and the resulting abnormal telomere lengthening by telomerase.

 

POSTDOCTORATE, Peggy Qiu (ybillin1@jhu.edu)

Peggy obtained her B.S. degrees in Biomedical Engineering and Electrical Engineering from Duke University. She got her M.S. degree in Bioengineering from the University of Illinois, focused on the use of ultrasound imaging in the diagnosis of breast cancer. She has currently obtained a Ph.D. degree in Prof. Sua Myong's lab, with research focused on proteins involved in DNA recombination and the remodeling of nucleosomes. Her current research focuses on intrinsically disordered proteins that are prevalent in neurodegenrative diseases such as ALS. In her free time, Peggy enjoys cooking, amateur model building and playing peacekeeper between the baby and the cats.

 

POSTDOCTORATE, Tapas Paul (tpaul6@jhu.edu)

Tapas obtained his B.Sc and M.Sc in chemistry from Calcutta University and also Ph.D. in chemistry from Saha Institute of Nuclear Physics, West Bengal, India. He joins Prof. Sua Myong’s lab as a postdoc at Johns Hopkins University. His research interest was on DNA breathing, looping dynamics and now focus on ‘how the oxidative lesions impacts on the telomeric structural properties and conformational dynamics and also telomerase accessibility and activity’ at single-molecule level. In his free time, he likes to play cricket, football, badminton and enjoys cooking.

 

GRADUATE STUDENT, Jim Lee (clee261@jhu.edu)

Jim obtained his B.S. and M.S. degree in Chemistry from National Taiwan University. He has joined Myong’s group since 2014. His research is focused on a special nucleic acid secondary structure, called G quadruplex (GQ) and its mysterious role in the central dogma. Combining both in vitro and in vivo methods, he has systematically investigated the effect of GQ in the transcription and translation processes. In addition, he also applies single-molecule technique to elucidate how GQ affects transcription and RNA polymerase under molecular level.

 

GRADUATE STUDENT, Amirhossein Ghanbari Niaki (aghanba1@jhu.edu)

Amirhossein joined the lab in 2015 and he is from a town close to the Caspian Sea in Iran. He obtained his BS and MS in Material Science and Engineering from Sharif University of Technology (SUT) in Tehran and Koç University in Istanbul, respectively. His research interest is utilizing single molecule techniques to understand the role of intrinsically disordered proteins such as FUS in the context of stress granules. His effort is focused on how different patient occurring mutations in FUS mechanistically lead to ALS and understand what are the mechanisms to dissolve these FUS aggregates.

 

GRADUATE STUDENT, Kevin Rhine (krhine1@jhu.edu)

Kevin is a Ph.D student from the CMDB program. He earned his BA with honors in Biochemistry & Molecular Biology and his MA in Biotechnology from Boston University in 2017. His project centers around determining early steps of FUS-mediated ALS pathogenesis, especially how ALS-linked FUS variants drive aggregation even in teh presence of wild-type FUS.

 

GRADUATE STUDENT, Gabby Vidaurre (vvidaur1@jhu.edu)

Gabby is a graduate student co-mentored by Dr. Xin Chen in the CMDB program. She earned her BA in Biology from The college of William and Mary in 2017. Her project involves characterization of an ALS-linked protein variant of FUS.

 

UNDERGRADUATE STUDENT, Walter Zhao (walter.zhao@jhu.edu)

Walter is a Biomedical Engineering undergraduate working with Dr. Ramreddy Tippana. Besides research,he is also a quiz bowl enthusiast and amateur Go player.

 

UNDERGRADUATE STUDENT, Joshua Choe (jchoe20@jhu.edu)

Josh is a sophomore Biophysics major at Johns Hopkins from the great state of Colorado. His mentor in the lab is the amazing and very patient Dr. Hui-Ting Lee. When Josh is not working in the lab, he volunteers at a Spanish clinic in East Baltimore and serves as a bible study leader for Intervarsity at Hopkins.  

 

UNDERGRADUATE STUDENT, Kevin Ma (kma8@jhu.edu)

Kevin is currently a Junior pre-medical student studying Biophysics at Johns Hopkins. He's originally from Seattle, Washington and when he has free time he enjoy camping, hiking, and kayaking.

 

UNDERGRADUATE STUDENT, Sachin Govind (sgovind3@jhu.edu)

Sachin is a second-year Molecular and Cellular Biology undergraduate student at JHU who recently joined Dr. Myong's research team. Following his graduation in 2018, he hopes to attend graduate school studying Biological Sciences and then medical school. In his free time, Sachin enjoys playing piano, spending time with friends, and reading.

 

UNDERGRADUATE STUDENT, Sophie Shoemaker (sshoema4@jhu.edu)

Sophie is an undergraduate Biophysics major and Computer Science minor at Hopkins. She is currently learning single-molecule techniques in the lab and working on characterizing DNA helicases and their ability to resolve g-quadruplex structures using smFRET. In her free time Sophie enjoys hiking, caving and playing board games.

 

UNDERGRADUATE STUDENT, Chaney Tse (ctse6@jhu.edu)

Chaney is from Monterey Park, CA, and his research in the Myong Lab involves investigating applications of the dynamic light scattering technique. Regardless of where he end up in the future, he'd just like to have a pet bird 😊

 

UNDERGRADUATE STUDENT, Xinyi Cai (xcai11@jhu.edu)

Xinyi is sophomore in Biophysics at Hopkins. She joined the lab in the Spring of 2017. Xinyi is deeply involved in RNP phase separation project to understand molecular basis of neurodegeneration.

 

Gloria is a college senior at Caltech who designed the template of this website and hand drew all the avatar figures on the members page. We appreciate her artistic touches pervasive all throughout our website!  Thanks, Gloria!!!

 

 

Alumni
Hye Ran Koh - Chung-Ang University, Korea, Assistant Professor
Alex Kreig - The Climate Corporation, Senior Agronomic Data Scientist
Younghoon Kim - Genzyme, Staff Scientist
Shirley Wang - Lawyer, China
Jacob Calvert - University of Bristol, Mathematics graduate student
Mallory Shroeder - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Blake Wilhelmsen - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Partha Ryali - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Janet Sanoica - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Brendan Pullen - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Emily Cullen - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Sarthak Grover - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Grace Kim - University of Illinois at Urbana-Champaign, Neuroscience graduate student
Lauren Grant - University of Illinois at Urbana-Champaign, Bioengineering undergraduate student
Helen Hwang - Barnes-Jewish Hospital, Resident Physician
Molly Imgruet - University of Chicago, MSTP student
Tiffany Sum - UCSF School of Dentistry student
Jason Xu - Bloomberg LP, Software Developer
Weikun Xiao - UCLA, Bioengineering graduate student
Amanda Hayward - University of Minnesota-Twin Cities, Biochemistry graduate student
Alex Loiben - Cornell University, Molecular and Cellular Tissue Engineering graduate student
Justin Drawz - SIMnext, Simulation Engineer
Divya Srinivasan - Consultant, Inventiv Health
Jamie Kelly
Meghan McCleary - University of Illinois at Urbana-Champaign, Extension Educator
Shayan Guhaniyogi - Biotronik, Engineer
Ensun Kwon
Zita Hubler
Thomas Leslie Deleon